Andy Samberg as Jose Canseco

Akiva Schaffer as Mark McGwire

Jorma Taccone as Reporter / Walt Weiss / Joe Montana

Hannah Simone as Amber

Jenny Slate as Stacy

Sterling K. Brown as Sia

Jim O'Heir as Puka Shell Bob

Stephanie Beatriz as Val Gal

Alana Haim as Val Gal

Este Haim as Val Gal

Danielle Haim as Val Gal

Maya Rudolph as Val Gal

Ben Perez as Jose's Dad

Dave Faulkner as Mark's Dad

Denise Weintraub as Marks Mom

Trinity Chanel as Madonna

Sis Gold as Mrs. McGillicutty

Whitney Moore as Snow Bunny

Kyla Billings as Bikini Girl

Britta Grant as Bikini Girl

Jonetta Kaiser as Bikini Girl

Julia Nolan as Bikini Girl

Dan Wicksman as Maitre D

Jeff Torres as Lenny the Torso

Ryan Nemeth as Reporter (uncredited)

Tory Taranova as Reporter (uncredited)