Owen Wilson as Greg Wittle

Salma Hayek Pinault as Isabel Clemens

Nesta Cooper as Emily Wittle

Jorge Lendeborg Jr. as Arthur Wittle

Ronny Chieng as Kendo

Steve Zissis as Bjorn

Joshua Leonard as Cameron

Madeline Zima as Doris

Bill Nye as Chris

Slavoj Žižek as Slavoj Žižek

DeRon Horton as Liang

Eugene Young as Bartender Todd

Dayne Catalano as Fast Food Clerk

Adam Zastrow as Dougie

Lora Lee as Destiny

Darin Cooper as Sketchy Man

Roberto Montesinos as Pawn Store Clerk

Kosah Rukavina as Young Emily

Tanya Alexander as Shelter Worker

Debbie Fan as Dr. Huang

K.T. Thangavelu as Esteemed Guest #2

Kayla Adams as Esteemed Guest #3

Gichi Gamba as Esteemed Guest #4

Manny Cartier as Police Officer

Mercy Malick as News Reporter

Branko Smiljanić as Professor Campbell

Sanja Vejnović as Professor Fluke

Guy Perry as Andy Warhol

Damien D. Smith as Group Leader

Heath McGough as Arnold

Hassan Abdelghani as Farmer

Upasana Beharee as Motel Clerk

Roshan Golconda as Brad

Jock McKissic as Security Guard

Whitney Brown as Streetwalker #2

Vanessa Knight as Streetwalker #3

Linda Wang as Streetwalker #4

Dayna Dooley as Police

Marcus Bailey as Arthur's Friend #1

Amanda Juni as Arthur's Friend #2

Jim Palmer as Officer

Tommy Franklin as Executive Colleague

Candice Heiden as Skater

Bella Cruz as Skater

Ryan Allen Carrillo as Skater

Courtney Enea as Skater

Zach Hainey as Skater

Derek Leonard as Skater

Elaine Reid as Skater

Crystal Rosenborough as Skater

Noah Valinsky as Skater

Appelusa McGlynn as Skater

Erin Flannery as Police Officer (uncredited)

Megan Le as Black Tie Guest (uncredited)

Katie McCabe as Roller Girl Lab Tech (uncredited)

Bowie Bundlie as Roller Disco Boy (uncredited)

Daniel Hoffman as Roller Disco Son (uncredited)

Bradley Bundlie as Roller Disco Boy (uncredited)