Melissa McCarthy as Lydia Berman

Octavia Spencer as Emily Stanton

Jason Bateman as The Crab

Bobby Cannavale as The King

Pom Klementieff as Laser

Melissa Leo as Allie

Taylor Mosby as Tracy

Marcella Lowery as Grandma Norma

Melissa Ponzio as Rachel Gonzales

Ben Falcone as Kenny

Nate Hitpas as Walter

Jevon White as Robber 1

David Storrs as Andrew (Robber 2)

Kevin Dunn as Frank

Henry Bazemore Jr. as Emily's Father

Mikia Jeter as Emily's Mother

Steve Mallory as Mr. Emerson

Bria Danielle Singleton as Young Emily

Tai Leshaun as Teen Emily

Vivian Falcone as Young Lydia

Mia Kaplan as Teen Lydia

Trevor Larcom as Young Clyde

Jackson Dippel as Young Wayne

Braxton Bjerken as Young Wayne's Friend

Tyrel Jackson Williams as Jessie

Sarah Baker as Sarah (Security Guard)

Jeryl Pennyman as Cashier

Jon Patrick Walker as Police Officer #1

Sherrell Hubbard as Newscaster

Thomas Roberts as Newscaster #2

Isaac Hughes as Tony (Boxing Instructor)

Brendan Jennings as Clyde

John Crow as Reporter #1

Valerie Sue Love as Reporter #2

Brandon M. Shaw as King's Goon #1

Keil Oakley Zepernick as King's Goon #2

Jenna Perusich as Newscaster #3

Damon Jones as Waiter

Georgette Falcone as Evelyn

Danielle Gautier as Rachel's Assistant

Tim Lovestedt as Cement Truck Driver

Jeniffer Watkins as Compound Employee

Courtney Patterson as Cop