Benedict Cumberbatch as Louis Wain

Claire Foy as Emily Wain

Andrea Riseborough as Caroline Wain

Toby Jones as Sir William Ingram

Sharon Rooney as Josephine Wain

Aimee Lou Wood as Claire Wain

Hayley Squires as Marie Wain

Stacy Martin as Felicie Wain

Phoebe Nicholls as Mrs Wain

Adeel Akhtar as Dan Rider

Asim Chaudhry as Herbert Railton

Taika Waititi as Max Kase

Crystal Clarke as Alicia Simmonds

Daniel Rigby as Bendigo

Richard Ayoade as Henry Wood

Julian Barratt as Dr Elphick

Dorothy Atkinson as Mrs Du Frayne

Nick Cave as H.G. Wells

Olivia Colman as Narrator

Fehinti Balogun as Praga

Jamie Demetriou as Woodville Jr.

Sophia Di Martino as Judith

Siobhán McSweeney as Dr Cooke

Stewart Scudamore as Dr Quantock

Simon Munnery as Jem Mace

James Eeles as Train Attendant

Olivier Richters as Journeyman Boxer

Indica Watson as Young Felicie Wain

Dorothy Atkinson as Mrs. DuFrayne

Kiki May as Paper Girl (1891)