Arnold Schwarzenegger as Dr. Alex Hesse

Danny DeVito as Dr. Larry Arbogast

Emma Thompson as Dr. Diana Reddin

Frank Langella as Noah Banes

Pamela Reed as Angela

Aida Turturro as Louise

James Eckhouse as Ned Sneller

Megan Cavanagh as Willow

Welker White as Jenny

Kathleen Chalfant as Casitas Madres Receptionist

Merle Kennedy as Samantha

Judy Collins as Naomi

Mindy Seeger as Alice

Christopher Meloni as Mr. Lanzarotta

Antoinette Peragine as Mrs. Lanzarotta

Cassandra Wilson as Singer

Ellen McLaughlin as Chairwoman (FDA)

Stefan Gierasch as Edward Sawyer

Alexander Enberg as Arthur

Judy Ovitz as Stewardess

Kevin West as Lyndon Executive

Ira Newborn as Lyndon Executive

Misa Koprova as Lyndon Receptionist

Jodi Knotts as Waiting Room Woman

Michele Abrams as Waiting Room Woman

John Pinette as Clerk

Fred Stoller as Waiter

Anna Gunn as Casitas Madres Receptionist

Lisa Summerour as Casitas Madres Exercise Attendant

Kristina Hardee as Casitas Madres Exercise Attendant

Leah Teweles as Mrs. Logan

Maggie Han as Lab Assistant

Charmaine Alicia Mancil as Scanner Guard

Lawrence Tierney as Mover

Matt Mulhern as Mover

Christopher Pray as Reporter

John Yang as Reporter

Sara Peery as Reporter

Jan Yanehiro as Reporter

Dennis O'Donnell as Reporter

Beth Campbell Fitzgerald as Reporter

Lawrence T. Wrentz as Campus Security Guard

Brianna McConnell as Junior

Brittany McConnell as Junior

Ryan Doss as Jake

Zachary Doss as Jake

Christian Giammichele as Library Baby

Kieran Giammichele as Library Baby

Monika Schnarre as Angelic Nurse

Allen Walls as Banquet Waiter

Kevin Sifuentes as Banquet Valet

Tom Dugan as Lobster Man

Holly Wortell as Lobster Woman

Susan Dills as Campus Gals

Maggy Myers Davidson as Campus Gals

Peter Chen as Taxi Driver

Dean Jacobson as Turkel

Mary Gordon Murray as Betty

Julie Nunis as Ticket Agent

Dayna Winston as Stewardess at Boarding Gate

Brandon Ross as Banquet Musician

Lonnie Plaxico as Banquet Musician

Jeff Haynes as Banquet Musician

Steven 'Lance' Carter as Banquet Musician

Charles Burnham as Banquet Musician

Dee Hengstler as Banquet Dancer

Bubba Dean Rambo as Banquet Dancer

Daryl Richardson as Banquet Dancer

Jerald Vincent as Banquet Dancer

Nina DeNike as Banquet Dancer

Maurice Schwartzman as Banquet Dancer

Kim Wolfe as Banquet Dancer

Charles McGowan as Banquet Dancer

Matt Birman as Lab Security Guard (uncredited)

Tracey Walter as Janitor with Information