Antonio Banderas as Dr. Robert Ledgard

Elena Anaya as Vera Cruz

Marisa Paredes as Marilia

Jan Cornet as Vicente

Roberto Álamo as Zeca

Eduard Fernández as Fulgencio

José Luis Gómez as Presidente del Instituto de Biotecnología

Blanca Suárez as Norma Ledgard

Susi Sánchez as Madre de Vicente

Bárbara Lennie as Cristina

Fernando Cayo as Médico

Chema Ruiz as Policía

Buika as Cantante

Ana Mena as Norma Joven

Teresa Manresa as Casilda Efraiz

Fernando Iglesias as

Agustín Almodóvar as Agustín

Miguel Almodóvar as Hijo de Agustín

Marta R. Mahou as Profesora de Yoga en TV

Esther García as Presentadora (uncredited)

Yolanda Brown as Conference participant