Antonio Banderas as Dr. Robert Ledgard

Elena Anaya as Vera Cruz / Gal

Marisa Paredes as Marilia

Jan Cornet as Vicente

Roberto Álamo as Zeca

Eduard Fernández as Fulgencio

José Luis Gómez as President of the Institute of Biotechnology

Blanca Suárez as Norma Ledgard

Susi Sánchez as Vicente's mother

Bárbara Lennie as Cristina

Fernando Cayo as Surgeon

Chema Ruiz as Police officer

Buika as Singer

Ana Mena as Young Norma

Teresa Manresa as Casilda Efraiz

Agustín Almodóvar as Agustín

Miguel Almodóvar as Agustín's son

Marta R. Mahou as Yoga teacher on TV

Esther García as Presenter (uncredited)

Yolanda Brown as Conference participant