Isabela Merced as Lucky Prescott (voice)

Julianne Moore as Aunt Cora (voice)

Marsai Martin as Prudence Granger (voice)

Mckenna Grace as Abigail Stone (voice)

Walton Goggins as Hendricks (voice)

Jake Gyllenhaal as Jim Prescott (voice)

Gary A. Hecker as Horse Vocals (voice)

Eiza González as Milagro Navarro Prescott (voice)

Andre Braugher as Al Granger (voice)

Lucian Perez as Snips Stone (voice)

Joe Hart as James Prescott Sr. (voice)

Alejandra Blengio as Valentina (voice)

Bridget Hoffman as Baby Lucky Prescott (voice)

Jerry Clarke as Wrangler / Llama Cowboy (voice)

Gino Montesinos as Wrangler / Rodeo Cowboy (voice)

Gary Anthony Williams as Wrangler (voice)

Renie Rivas as Lady with Dog (voice)

Lew Temple as Conductor (voice)

Eric Tiede as Townsfolk