Lorenzo Music as Garfield (voice)

Thom Huge as Jon Arbuckle/ Caveman #1 / Junior / Soldier / Computer (voice)

Gregg Berger as Odie / Jester / Scientist #1 / Cave Cat Narrator (voice)

Desiree Goyette as Chloe / Sara (voice)

Nino Tempo as Luigi / Black Bart (voice)

Hal Smith as George Frideric Handel / Larry (voice)

Heather Kerr as Little Sara (voice)

Sandi Huge as Garfield's Mother / Sara's Mother (voice)

Carolyn Davis as Older Sara (voice)

Frank Welker as Commander Mendelson (voice)

C. Lindsay Workman as God (voice)

Ed Bogas as Additional Voices (voice)