Frankie Muniz as Stripes (voice)

Hayden Panettiere as Channing Walsh

Bruce Greenwood as Nolan Walsh

Mandy Moore as Sandy (voice)

Wendie Malick as Clara Dalrymple

M. Emmet Walsh as Woodzie

Snoop Dogg as Lightning (voice)

Michael Clarke Duncan as Clydesdale (voice)

Jeff Foxworthy as Reggie (voice)

Whoopi Goldberg as Franny (voice)

Steve Harvey as Buzz (voice)

David Spade as Scuzz (voice)

Dustin Hoffman as Tucker (voice)

Joshua Jackson as Trenton's Pride (voice)

Joe Pantoliano as Goose (voice)

Michael Rosenbaum as Ruffshodd (voice)

Gary Bullock as John Cooper

Fred Thompson as Sir Trenton (voice)

Caspar Poyck as Mailman

Thandi Puren as Reporter

Morné Visser as Reporter

Dawn Matthews as Reporter

Matt Stern as Reporter

John Lesley as Paddock Boss

Graeme Hawkins as Track Announcer

Tarryn Meaker as Anthem Singer

Jansen Panettiere as Young Stripes (voice)

Frankie Ryan Manríquez as Young Ruffshodd (voice)

Kyle Alcazar as Young Pride (voice)

Dee Bradley Baker as Additional Voices (voice)

Bob Bergen as Additional Voices (voice)

Jess Harnell as Additional Voices (voice)