Will Smith as Robert Neville

Alice Braga as Anna Montez

Charlie Tahan as Ethan

Dash Mihok as Alpha Male

Salli Richardson-Whitfield as Zoe Neville

Willow Smith as Marley Neville

Emma Thompson as Dr. Alice Krippin

Darrell Foster as Mike - Military Escort

Joanna Numata as Alpha Female

Samuel Glen as Military Driver - Jay

Pedro Mojica as Sergeant

Marin Ireland as Woman Evacuee

Alexander DiPersia as Male Evacuee

April Grace as TV Personality

James McCauley as Male Evacuee

Anthony C. Mazza as Evacuation Cop

Steve Cirbus as Military Police

Calista Hill as Little Girl Evacuee

Gabriella Hill as Little Girl Evacuee

Madeline Hill as Little Girl Evacuee

Adhi Sharma as Military Scanning Tech

Tyree Michael Simpson as Evacuation Cop #2

Blake Lange as Coast Guard Ground Crew

Abraham Sparrow as Male Evacuee #3

Pat Fraley as President (voice)

Caitlin McHugh as Special Blond Model

Deborah Collins as Civilian

Mike Patton as Creatures (voice)

Katherine Brook as Infected

Vince Cupone as Infected

Lynna' Davis as Infected

Anika Ellis as Infected

John Grady as Infected

Moses Harris Jr. as Infected

Kennis Hawkins as Infected

Marc Inniss as Infected

Eric Jenkins as Infected

Reed Kelly as Infected

Grasan Kingsberry as Infected

Drew Leary as Infected

Asa Liebmann as Infected

Deborah Lohse as Infected

Jon-Paul Mateo as Infected

Ian Mclaughlin as Infected

Luke Miller as Infected

Courtney Munch as Infected

Kimberly Shannon Murphy as Infected

Okwui Okpokwasili as Infected

Erin Owen as Infected

Victor Paguia as Infected

Paradox Pollack as Infected

Will Rawls as Infected

William Schultz as Infected

Hollie K. Seidel as Infected

Hannah Sim as Infected

Eric Spear as Infected

Mark Steger as Infected

Charlie Sutton as Infected

David Hamilton Thomson as Infected

Anthony Vincent as Infected

Greg Wattkis as Infected

Raul Torres as Male Evacuee (uncredited)