Franco Nero as Keoma

William Berger as William John Shannon

Olga Karlatos as Liza Farrow

Orso Maria Guerrini as Butch Shannon

Gabriella Giacobbe as The Witch

Antonio Marsina as Lenny Shannon

Joshua Sinclair as Sam Shannon

Donald O'Brien as Caldwell

Leonardo Scavino as Doctor

Wolfango Soldati as Wolf

Victoria Zinny as Saloon Hooker

Alfio Caltabiano as Clay

Woody Strode as George

Roberto Dell'Acqua as Jeff (uncredited)

Riccardo Pizzuti as Slade (uncredited)

Pierangelo Civera as Plague Victim (uncredited)

Ian Danby as Saloon Bartender (uncredited)

Catharina Dahlin as Woman Receiving Medicine (uncredited)

Massimo Vanni as Caldwell's Henchman at Wagon (uncredited)

Sergio Ruggeri as Caldwell's Henchman at Saloon (uncredited)

Giovanni Cianfriglia as Caldwell's Henchman (uncredited)

Franco Ukmar as Caldwell's Henchman (uncredited)

Angelo Ragusa as Caldwell's Henchman (uncredited)

Antonio Basile as Caldwell's Henchman (uncredited)

Giovanni Ukmar as Caldwell's Henchman (uncredited)

Augusto Funari as Caldwell's Henchman (uncredited)

Roberto Messina as Caldwell's Henchman (uncredited)

Giovanni Bonadonna as Caldwell's Henchman (uncredited)

Aldo Canti as Caldwell's Henchman (uncredited)

Sergio Ukmar as Caldwell's Henchman (uncredited)

Giancarlo Ukmar as Caldwell's Henchman (uncredited)

Paolo Figlia as Caldwell's Henchman (uncredited)

Angelo Giusto as Caldwell's Henchman (uncredited)

Maurizio Mannoia as Caldwell's Henchman (uncredited)

Felice Ceciarelli as Caldwell's Henchman (uncredited)

Claudio Ruffini as Caldwell's Henchman (uncredited)