Tobin Bell as John Kramer / Jigsaw

Costas Mandylor as Mark Hoffman

Scott Patterson as Agent Strahm

Betsy Russell as Jill Tuck

Lyriq Bent as Rigg

Athena Karkanis as Agent Perez

Louis Ferreira as Art

Simon Reynolds as Lamanna

Donnie Wahlberg as Eric Matthews

Angus Macfadyen as Jeff Denlon

Shawnee Smith as Amanda Young

Bahar Soomekh as Lynn Denlon

Dina Meyer as Detective Allison Kerry

Mike Realba as Fisk

Marty Adams as Ivan

Sarain Boylan as Brenda

Billy Otis as Cecill

James Van Patten as Dr. Heffner / Coroner

David Boyce as Pathologist

Kevin Rushton as Trevor

Julian Richings as Vagrant

Kelly Jones as SWAT Pete

Ingrid Hart as Tracy Rigg

Niamh Wilson as Corbett Denlon

Janet Land as Morgan

Ron Lea as Rex

Joanne Boland as Crime Scene Photographer

Zoe Heath as Lab Technician

Bill Vibert as Young Cop

Eric Gores as Matt

Devon Bostick as Derek

Tony Nappo as Gus

Emmanuelle Vaugier as Addison Corday

Noam Jenkins as Michael Marks

Mike Butters as Paul Leahy

J. LaRose as Troy

Oren Koules as The Man

Alison Luther as Young Girl

Kim Roberts as Nurse Deborah

David Webster as Dr. Steve

Sandra Manson as Nurse Patti

Shauna Black as Additional Voice Talent (voice)

Darrell Dennis as Additional Voice Talent (voice)

Tracey Ferencz as Additional Voice Talent (voice)

Catherine Fitch as Additional Voice Talent (voice)

Christopher Marren as Additional Voice Talent (voice)

Christopher Morris as Additional Voice Talent (voice)

Geoffrey Pounsett as Additional Voice Talent (voice)