Riccardo Scamarcio as Caravaggio

Louis Garrel as The Shadow

Isabelle Huppert as Costanza Sforza Colonna

Vinicio Marchioni as Giovanni Baglione

Lolita Chammah as Anna Bianchini

Micaela Ramazzotti as Lena Antonietti

Alessandro Haber as Battista

Michele Placido as Cardinal Del Monte

Brenno Placido as Ranuccio

Moni Ovadia as Filippo Neri

Lorenzo Lavia as Orazio Gentileschi

Tedua as Cecco

Maurizio Donadoni as Papa Paolo V

Gianfranco Gallo as Giordano Bruno

Gianluca Gobbi as Scipione Borghese

Duccio Camerini as Costantino Spada

Carlo Giuseppe Gabardini as Onorio Longhi

Sebastiano Lo Monaco as Alof di Wignacourt

Guia Jelo as Serva di Caravaggio

Michelangelo Placido as Fratello di Ranuccio

Alberto Onofrietti as Cugino di Ranuccio

Pietro Micci as Inquisitore

Davide Paganini as Cavalier d'Arpino

Lea Gavino as Artemisia Gentileschi

Tommaso De Bacco as Fabrizio Colonna

Orfeo Orlando as Sottoposto Cardillo

Sandro Presta as Guerico

Gerardo D'Angelo as Butterato

Leo Mantovani as Frate Girolamo

Federico Fiorio as Pedro Montoya

Ciro Cascina as Mammeta

Marco Mancassola as Macellaio

Prince Chidozie Manujibeya as Otello

Silvia Siravo as Desdemona

Terenzio Del Gaudio as Sgherro

Alessandro Luzzi as Paolino

Luigi Chiocca as Carcerato