Andie MacDowell as Ann Finnigan

Bruce Davison as Howard Finnigan

Jack Lemmon as Paul Finnigan

Tim Robbins as Gene Shepard

Julianne Moore as Marian Wyman

Tom Waits as Earl Piggot

Lily Tomlin as Doreen Piggot

Fred Ward as Stuart Kane

Chris Penn as Jerry Kaiser

Frances McDormand as Betty Weathers

Madeleine Stowe as Sherri Shepard

Jennifer Jason Leigh as Lois Kaiser

Anne Archer as Claire Kane

Matthew Modine as Dr. Ralph Wyman

Lili Taylor as Honey Bush

Robert Downey Jr. as Bill Bush

Peter Gallagher as Stormy Weathers

Zane Cassidy as Casey Finnigan

Joseph C. Hopkins as Joe Kaiser

Josette Maccario as Josette Kaiser

Austin Friel as Austin Shepard

Dustin Friel as Will Shepard

Cassie Friel as Sandy Shepard

Jarrett Lennon as Chad Weathers

Buck Henry as Gordon Johnson

Huey Lewis as Vern Miller

Dirk Blocker as Diner Customer

Alex Trebek as Alex Trebek

Jerry Dunphy as Jerry Dunphy

Lyle Lovett as Andy Bitkower

Lori Singer as Zoe Trainer / Cello - The Trout Quintet

Danny Darst as Aubrey Bell

Annie Ross as Tess Trainer

Robert DoQui as Knute Willis

Margery Bond as Dora Willis (as Margerie Bond)

Darnell Williams as Joe Robbins

Michael Beach as Jim Stone

Andi Chapman as Harriet Stone

Deborah Falconer as Barbara

Susie Cusack as Nancy

Charles Rocket as Wally Littleton

Jane Alden as Mrs. Schwartzmeier

Christian Altman as Jimmy Miller

William H.D. Marlett as Jimmy's Friend

Suzanne Calvert as Tarmac Secretary

Natalie Strong as Mourner

Jay Della as Bartender

Jeri Gray as Club Owner (as Jeruth Persson)

Derek Webster as Joe Robbins' Pal

Nathaniel Harris as Joe Robbins' Pal (as Nathaniel H. Harris III)

Ron McPherson as Makeup Artist

Paul Parkey Jr. as Diner Patron