Dhanush as Sivaramakrishnan / Dhandapani

Genelia D'Souza as Pooja Padmanadhan

Vivek as 'Emotional' Ekambaram

K. Bhagyaraj as Raghupathi/Washington Vetrivel

Ashish Vidhyarthi as Periyamuthu Gounder

Jayaprakash Reddy as Chinnamuthu Gounder

Sundarrajan as Sundaram

Karunas as Janaki

Vijay Babu as Raghavan / Chicago Shakthivel

Charu Haasan as Swamiji

Mayilsamy as Santhosh Kanth

Srinath as David

Pandu as Swamiji's Assistant

Rajendran as Velu

Ambika as Sivakaami

Rekha as Meenakshi

Rajyalakshmi as Lakshmi Raghupathi

Nithya as Bharatham Sundaram

Uma Padmanabhan as Sundari Raghavan

Aarthi as Raji/Gundumani

Surekha Vani as Chinnamuthu's daughter-in-law

Shriya Saran as Kalpana (Guest Appearance)