Chris Hemsworth as Orion Pax / Optimus Prime (voice)

Brian Tyree Henry as D-16 / Megatron (voice)

Scarlett Johansson as Elita-1 (voice)

Keegan-Michael Key as B-127 (voice)

Jon Hamm as Sentinel Prime (voice)

Steve Buscemi as Starscream (voice)

Laurence Fishburne as Alpha Trion (voice)

Vanessa Liguori as Airachnid (voice)

Jon Bailey as Soundwave (voice)

Jason Konopisos-Alvarez as Shockwave / Guard 2 (voice)

Evan Michael Lee as Jazz (voice)

James Remar as Zeta Prime (voice)

Isaac C. Singleton, Jr. as Darkwing (voice)

Steve Blum as Announcer Bot / Guard 1 (voice)

Jinny Chung as Chromia / Arcee (voice)

Josh Cooley as Control Room Guys / PA System / Skywarp (voice)

Dillon Bryan as Injured Racer (voice)