Michael Chiklis as Slade Wilson / Deathstroke (voice)

Sasha Alexander as Adeline 'Addie' Kane Wilson (voice)

Chris Jai Alex as Jackal (voice)

Faye Mata as H.I.V.E. Queen / Jade (voice)

Griffin Puatu as Joseph Wilson / Jericho (voice)

Asher Bishop as Young Joseph Wilson (voice)

Imari Williams as President Nicholas / H.I.V.E. Pilot (voice)

Colin Salmon as William Wintergreen (voice)

Delbert Hunt as Bronze Tiger (voice)

Panta Mosleh as Lady Shiva / Nurse (voice)

Noshir Dalal as Kapoor / Doctor 2 (voice)

Castulo Guerra as General Suarez / Doctor (voice)

Minae Noji as Newscaster / Secretary of State (voice)