Michael Shannon as Shriver

Kate Hudson as Simone Cleary

Don Johnson as T. Wasserman

Da'Vine Joy Randolph as Delta Jones

Mark Boone Junior as Lenny

Zach Braff as Real Shriver

Perry Mattfeld as Layla

Aja Naomi King as Blythe Brown

M. Emmet Walsh as Arthur Baldwin

Jimmi Simpson as Detective Karpas

Peyton List as Sophie Firestone

Wendie Malick as Dr. Bedrosian

Natasha Hall as Virginia

David Cade as Cheadum

Benjamin King as Jack Blunt

Adhir Kalyan as Victor Bennet

Reid Miller as Dylan

Kate Linder as College President

Giorgia Whigham as Charlie

Romy Byrne as Teresa

Spencer Squire as Conrad

Jack Gilpin as Narrator (Voice)

Tiffany Bank as Rose

Mark Brocksmith as Man in Bathrobe

Jordan Feldman as TSA Agent

Ashlei Foushee as Jodie

Winston Salk as Justin

Antonio Wilson as ASL Interpreter

Nicolette Hogan as Liquor Store Clerk