Steve Carell as Dan

Juliette Binoche as Marie

Dane Cook as Mitch

Alison Pill as Jane

Britt Robertson as Cara

Marlene Lawston as Lilly

Dianne Wiest as Nana

John Mahoney as Poppy

Emily Blunt as Ruthie Draper

Amy Ryan as Eileen

Norbert Leo Butz as Clay

Jessica Hecht as Amy

Frank Wood as Howard

Henry Priest Miller as Will

Ella Miller as Rachel

CJ Adams as Elliot

Jessica Lussier as Jessica

Seth D'Antuono as Gus

Margot Janson as Olivia

Willa Cuthrell-Tuttleman as Bella

Felipe Dieppa as Marty Barasco

Matthew Morrison as Policeman

Bernie McInerney as James Lamson

Amy Landecker as Cindy Lamson

Steve Mellor as Bookstore Clerk

Pauline Gregory as Bowling Alley Manager

Shana Carr as Suzanne Burns

Nicole Morin as Jane (age 13)

Charlotte Davies as Cara (age 11)

Zoe Pauliks as Lilly (age 4)

Lucas Hedges as Lilly's Dance Partner

Sondre Lerche as Himself

Kato Ådland as The Faces Down Wedding Band (Guitar)

Ole Ludvig Krüger as The Faces Down Wedding Band (Drums)

Morten Skage as The Faces Down Wedding Band (Bass)

Marci Occhino as Wedding Singer

John Franchi as NYC Cabbie (uncredited)