Gary Cooper as Captain Christopher Holden

Paulette Goddard as Abby

Howard Da Silva as Garth

Boris Karloff as Guyasuta, Chief of the Senecas

Cecil Kellaway as Jeremy Love

Ward Bond as John Fraser

Katherine DeMille as Hannah

Henry Wilcoxon as Captain Steele

C. Aubrey Smith as Lord Chief Justice

Victor Varconi as Captain Simeon Ecuyer

Virginia Grey as Diana

Porter Hall as Leach

Mike Mazurki as Bone

Richard Gaines as Colonel George Washington

Virginia Campbell as Mrs. John Fraser

Gavin Muir as Lieut. Fergus McKenzie

Alan Napier as Sir William Johnson

Ninetta Sunderland as Mrs. Pruitt

Marc Lawrence as Medicine Man Sioto

Jane Nigh as Evelyn

Raymond Hatton as Venango Scout

John Mylong as Colonel Henry Bouquet

George Kirby as London Astronomer Charles Mason

Leonard Carey as London Astronomer Jeremiah Dixon

Frank Wilcox as Richard Henry Lee

Davison Clark as Mr. Carroll of Virginia

Griff Barnett as Brother Andrews of Pennsylvania

Lloyd Bridges as Lieut. Hutchins

Oliver Thorndike as Lieut. Baillie

Rus Conklin as Mamaultee

Iron Eyes Cody as Red Corn

Julia Faye as Widow Swivens

Paul E. Burns as Dan McCoy

Mary Field as Maggie

Diane Wadelow as Lancashire Lass

Clarence Muse as Jason

Cecil B. DeMille as Self - Narrator (voice) (uncredited)

Dorothy Adams as Woman at Fort Pitt (uncredited)

James Flavin as Villager (uncredited)

Francis Ford as Frontiersman on Fort Pitt Roof (uncredited)

Byron Foulger as Townsman (uncredited)

Beulah Archuletta as Seneca Woman (uncredited)