Ben Stiller as Alex Rose

Drew Barrymore as Nancy Kendricks

Amber Valletta as Céline

Eileen Essell as Mrs. Connelly

Harvey Fierstein as Kenneth

Justin Theroux as Coop

Swoosie Kurtz as Jean

Jackie Sandler as Bartender

Robert Wisdom as Officer Dan

James Remar as Chick

Wallace Shawn as Herman

Maya Rudolph as Tara

Cheryl Klein as Ginger

Christopher Doyle as Tavern Bartender

Tim Maculan as Terrence

Christina Kirk as Mrs. Friedman

John Hamburg as Mr. Friedman

Jenette Goldstein as Moderator

Geraldine Hughes as Receptionist

Christine La Fontaine as Don Piper Fan #1

Joey Banks as Police Officer

Tracey Walter as Pharmacy Customer

Michelle Krusiec as Dr. Kang

Gary Riotto as Drug Dealer

Philip Perlman as Phil

Danny DeVito as Narrator (voice, uncredited)

Evgeniy Lazarev as Mr. Dzerzhinsky

Edward Edwards as Antique Dealer

Jim Castillo as Weatherman