Michelle Pfeiffer as Melanie Parker

George Clooney as Jack Taylor

Mae Whitman as Maggie Taylor, Jack's daughter

Alex D. Linz as Sammy Parker, Melanie's son

Charles Durning as Lew, Jack's boss

Jon Robin Baitz as Mr. Yates, Jr.

Ellen Greene as Mrs. Elaine Lieberman

Amanda Peet as Celia

Joe Grifasi as Manny Feldstein

Pete Hamill as Frank Burroughs

Anna Maria Horsford as Evelyn

Gregory Jbara as Freddy

Sheila Kelley as Kristen, Jack's ex-wife

Bitty Schram as Marla

Barry Kivel as Mr. Yates, Sr.

Robert Klein as Dr. Martin

George Martin as Mr. Smith Leland

Michael Massee as Eddie Parker

Holland Taylor as Rita

Rachel York as Liza

Marianne Muellerleile as Ruta

Steven Jang as Vincent Wang

Samantha Cintrón as Rosa Lopez

Victor Truro as Sammy's Pediatrician

Ashley Greenfield as Jessica

Sidney Armus as Mayor Sidney Aikens

Hal Panchansky as Metro Reporter

Maggie Wagner as Daily News Reporter

Isabelle Ashland as Daily News Reporter

Jasmin Hartmann as Daily News Reporter

Larry Sherman as Daily News Visitor

Shaun Duke as Foreign Artist Guy

Thomas Schall as Gentleman

Michael Badalucco as Lt. Bonomo

Jeanie Van Dam as Old Woman

Kirstin Allen as Pregnant Saleslady

Michael Genet as Mayor Aikens' Press Secretary

Julia Ryder Perce as Lew's Secretary

P.J. Aliseo as Spiderman

Liam Ahern as The Incredible Hulk

José Rabelo as Museum Guard

Darla Hill as Oribe's Receptionist

Joe Avellar as Reporter

Jullie Chung as Reporter

Dale Kasman as Lady in the Police Station

Andrew Magarian as Bum in the Police Station

Katherine Argo as Passerby #1

Rob Buntzen as Passerby #2

Brian Cahill as Passerby #3

Fred Goehner as Davis

Kuniko Narai as Flower Shop Employee

Gideon Jacobs as Billy (uncredited)