Steve Martin as Stu Preissler

Jack Black as Brad Harris

Owen Wilson as Kenny Bostick

Brian Dennehy as Raymond Harris

Anjelica Huston as Annie Auklet

Rashida Jones as Ellie

Rosamund Pike as Jessica

Dianne Wiest as Brenda Harris

JoBeth Williams as Edith

Anthony Anderson as Bill Clemont

Corbin Bernsen as Gil Gordon

Barry Shabaka Henley as Dr. Neil Kramer

Joel McHale as Barry Loomis

Tim Blake Nelson as Fuchs

Jim Parsons as Crane

Kevin Pollak as Jim Gittelson

Nate Torrence as Ted Simkin

Steven Weber as Rick

Zahf Paroo as Prasad

John Cleese as Historical Montage Narrator (voice)

Paul Campbell as Tony

Cindy Busby as Susie

Greg Kean as Computer Birder

Eva Bourne as Birder's Daughter

Bill Dow as Dr. Paul Elkin

June Squibb as Old Lady

Craig Bockhorn as Lawyer

Joey Aresco as Frank Falucci

Ryan Caltagirone as Frank Jr.

Al Roker as New York Weatherman

Christopher Mann as Security Guard

Jan Bos as Local Newsman (High Island)

Kate Gajdosik as Local Newswoman (High Island)

William Samples as British Tourist

Scott Patey as Birder (High Island)

Marci T. House as Troop Leader

Michael Bean as Waiter

Christopher Redman as Scott

Devon Weigel as Karen

Andrew Wilson as Mike Shin

Gabrielle Rose as Mary Swit

Calum Worthy as Colin Debs

Doreen Ramus as CB Announcer

Terence Kelly as Pete Shackelford

Steve Darling as Anchorage Weatherman

Jon Frankel as Anchorage Anchorman

David James Lewis as Lanky Birder

Jesse Moss as Darren

Kath Dugray as Motel Manager

Morgan Brayton as Ferry Ticket Seller

Sheelah Megill as Nurse

Veena Sood as Nurse Katie

Dee Jay Jackson as Parking Attendant

Calvin Lee as Chinese Waiter

Tshering Garie as Chinese Waitress

Michael Karl Richards as Vicki's Fiancée (uncredited)

Stacey Scowley as Vicki (uncredited)