Matt Damon as Cale Tucker (voice)

Bill Pullman as Captain Korso (voice)

Drew Barrymore as Akima (voice)

John Leguizamo as Gune (voice)

Nathan Lane as Preed (voice)

Janeane Garofalo as Stith (voice)

Ron Perlman as Prof. Sam Tucker (voice)

Alex D. Linz as Young Cale (voice)

Tone Loc as Tek (voice)

Jim Breuer as The Cook (voice)

Jim Cummings as Chowquin (voice)

Charles Rocket as Firrikash (voice)

Ken Hudson Campbell as Po (voice)

Tsai Chin as Old Woman (voice)

Crystal Scales as Drifter Girl (voice)

David L. Lander as Mayor of New Bangkok (voice)

Roger L. Jackson as First alien (voice)

Chris Scarabosio as Queen Drej (voice)

Elaine A. Clark as Citizen (voice)

Leslie Hedger as First Human (voice)

Roy Conrad as Second Human (voice)

Thomas A. Chantler as Male Announcer (voice)