Matt Damon as Cale (voice)

Bill Pullman as Korso (voice)

Drew Barrymore as Akima (voice)

John Leguizamo as Gune (voice)

Nathan Lane as Preed (voice)

Janeane Garofalo as Stith (voice)

Jim Breuer as The Cook (voice)

Ken Hudson Campbell as Po (voice)

Thomas A. Chantler as Male Announcer (voice)

Tsai Chin as Old Woman (voice)

Elaine A. Clark as Citizen (voice)

Roy Conrad as Second Human (voice)

Jim Cummings as Chowquin (voice)

Leslie Hedger as First Human (voice)

Roger L. Jackson as First Alien (voice)

David L. Lander as The Mayor (voice)

Alex D. Linz as Young Cale (voice)

Tone Loc as Tek (voice)

Ron Perlman as Sam Tucker (voice)

Charles Rocket as Firrikash / Slave Trader Guard (voice)

Crystal Scales as Drifter Girl (voice)

Chris Scarabosio as Queen Drej (voice)

Eric Schniewind as Alien (voice)

Stephen Stanton as Colonist (voice)