Joseph Cross as Augusten Burroughs

Annette Bening as Deirdre Burroughs

Brian Cox as Dr. Finch

Gwyneth Paltrow as Hope Finch

Joseph Fiennes as Neil Bookman

Evan Rachel Wood as Natalie Finch

Alec Baldwin as Norman Burroughs

Jill Clayburgh as Agnes Finch

Gabrielle Union as Dorothy

Patrick Wilson as Michael Shephard

Kristin Chenoweth as Fern Stewart

Dagmara Dominczyk as Suzanne

Colleen Camp as Joan

Jack Kaeding as Six-Year-Old Augusten Burroughs

Gabriel Guedj as Poo

Nancy Cassaro as Christy - 1978 Poetry Club

Omid Abtahi as Restaurant Manager

Julie Remala as Restaurant Waitress

Will Carter as Officer Button

Bonnie Weis as Cocktail Waitress

Dakotah Masset as Waitress

Marianne Muellerleile as Nurse

Anthony Aria as Audience Member (uncredited)

Augusten Burroughs as Self (uncredited)

Lindsay Canton as Co-Ed (uncredited)

Leslie Grossman as Sue (uncredited)

Joshua Levine as Chris (uncredited)

Margaret Newborn as Audience Member (uncredited)

Devanny Pinn as Poetry Club Member (uncredited)

Amy Rider as Sugar (uncredited)

Gary Sievers as Jewish Rabbi (uncredited)

Joseph Sims as Audience Member (uncredited)

Scott Slifer as Audience Member (uncredited)

Cole Volmer as College Student (uncredited)

Pilar Walsh as Professor's Wife (uncredited)

Rachel Zeskind as Deirdre Obsessed Fan (uncredited)