Massimo Boldi as Cristoforo Colombo

Anna Maria Barbera as Rosy Colombo

Enzo Salvi as Oscar Corleone

Bruno Arena as Bruno

Max Cavallari as Max

Biagio Izzo as Al Di Giacomo

Lucrezia Piaggio as Valentina Colombo

Loredana De Nardis as Lory

Victoria Silvstedt as Patricia Di Giacomo

Donald French as Bob Di Giacomo

Lodovica Mairè Rogati as Pamela

Oona O'Connell as Candice

Valentino Campitelli as Riky Colombo

Niccolò Senni as fidanzato di Alessia

Raffaello Balzo as Luca

Luigi Petrazzuolo as Maritozzo

Araba Dell'Utri as sorella di Maritozzo

Sofia Bruscoli as sorella di Luca

Barbara De Rossi as cartomante

Gigi Marzullo as Sè stesso

Solange as sè stesso

Valentina Idini as Alessia