Millie Bobby Brown as Michelle

Chris Pratt as Keats

Ke Huy Quan as Dr. Amherst / P.C (voice)

Jason Alexander as Ted / Wingman

Woody Norman as Christopher

Giancarlo Esposito as Colonel Bradbury / The Marshall

Stanley Tucci as Ethan Skate

Woody Harrelson as Mr. Peanut (voice)

Anthony Mackie as Herman (voice)

Brian Cox as Popfly (voice)

Jenny Slate as Penny Pal (voice)

Hank Azaria as Perplexo (voice)

Colman Domingo as Wolfe (voice)

Alan Tudyk as Cosmo (voice)

Ann Russo as Mom

Greg Cromer as Dad

Vince Pisani as Science Professor

Camrus Johnson as Corporal Carson

Juan Uribe Brandi as University Student

Kurt Loder as Kurt Loder

Roshni Edwards as Jessie

Holly Hunter as Madeline Vance

Will Lyman as Documentary Narrator (voice)

Aubrey Brockwell as Milkmatic Girl

Camille Marquez as Beachgoer / History Teacher Drone

Tuc Watkins as Arthur Meadows

Billy Gardell as Garbage Bot (voice)

Merle Dandridge as News Anchor

Ian McShay as Soldier

Anthony J. Vorhies as Staff Sergeant Stanisic

Walter Strickland as Drone Pilot (1991)

Joe Avena as President Clinton

Necar Zadegan as Farah Bedi

Lia Mariella Russo as Cheerleader

Marin Hinkle as Ms. Sablinsky

Brooklynn as Neurocaster Junkie

Antoinette LaVecchia as Elena Skate

Rahul Kohli as Miles Watlow

Michael Trucco as Ben Alcott

Joe Russo as Skeevy Bot (voice)

Rob Gronkowski as Blitz (voice)

Susan Leslie as Mrs. Scissors (voice)

Jordan Black as Clem (voice)

Andy Watts as Drone Pilot #1

Jeffrey Ford as Drone Pilot #2

Patrick Newall as Bumper Car Drone Pilot

Terence Lee as Cosmo Capture Drone

Alan Boell as Sentre Tech #1

Myles Alexander Evans as Sentre Tech #2

Patti Harrison as Ligotti

Chris Castaldi as Determined Drone Pilot

Christopher Brearton as Howard Cox

Augie Rosalina as High School Student

Terry Notary as Mr. Peanut / Pop Fly / Sentre Drones / Ice Cream Bot / Skeeve Bot

Adam Croasdell as The Marshall / Taco Bot / Sentry Bot / Blitz

Christopher Silvestri as P.C. / Perplexo / Construction Bot / Clem / Lieutenant Leeks / Garbage Can Bot

Devyn Dalton as Cosmo

Phoenix Notary as Young Cosmo

Gabrielle Maiden as Penny Pal / Mrs. Scissors / Happy Pill Bot / Sentre Drones

Martin Klebba as Herman / Milkman Bot

Katelin Chesna as Hospital Doctor (uncredited)

Sebastian Soler as Orderly (uncredited)

Bill Clinton as Himself (archive footage) (uncredited)

Nancy Pelosi as Herself (archive footage) (uncredited)