Rebel Wilson as Stephanie Conway

Sam Richardson as Seth Novacelik

Zoë Chao as Tiffany Blanchette-Balbo

Mary Holland as Martha Reiser

Justin Hartley as Blaine Balbo

Chris Parnell as Jim Conway

Angourie Rice as Young Stephanie Conway

Molly Brown as Young Martha Reiser

Zaire Adams as Young Seth Novacelik

Ana Yi Puig as Young Tiffany Blanchette

Tyler Barnhardt as Young Blaine Balboa

Jade Bender as Britney 'Bri Luvs' Balbo

Avantika as Janet

Joshua Colley as Yaz

Jeremy Ray Taylor as Neil Chudd

Michael Cimino as Lance Harrison

Brandon Scott Jones as Mr. T

Tiffany Denise Hobbs as Dr. Jean Johnson

Lauren Halperin as Nurse

Alicia Silverstone as Deanna Russo

Lucy Taylor as Lydia Conway

Merrick McCartha as Principal Young

Ruby Frankel as Drunk Person

Steve Aoki as Steve Aoki

John Crow as News Anchor

Mimi Gould as Movie Goer

Vance Kanell as Usher

Joel Ray Ishman as Chemistry Teacher

Vee Bhakta as Janet's Dad

Leonard R. Butler as Mr. Beenbaum

James Millar as Stoner Student's Dad

Darrell Snedeger as Deanna Russo's Husband

Alyssa Mae Clark as Young Deanna Russo

Grace Chan as Dancer