Leslie Odom Jr. as Victor Fielding

Lidya Jewett as Angela Fielding

Olivia O'Neill as Katherine West

Ann Dowd as Nurse Ann Brooks

Jennifer Nettles as Miranda West

Norbert Leo Butz as Tony West

Okwui Okpokwasili as Dr. Beehibe

Raphael Sbarge as Pastor Don Revans

E.J. Bonilla as Father Maddox

Ellen Burstyn as Chris MacNeil

Linda Blair as Regan MacNeil

Danny McCarthy as Stuart

Tracey Graves as Sorenne Fielding

Celeste Oliva as Detective Konik

Antoni Corone as Father Phillips

Norah Murphy as Hannah

Chloe Traicos as Joda Maxwell

Chandu Kanuri as Daniel

Richard Carr III as Dr. Carr

Malena Cunningham Anderson as News Reporter

Emily Rachel Gordon as Catholic Choir Member

Linda Boston as Principal

Nick Benas as Neighbor

Justin Paul Warren as Portrait Dad

Seth Loven as Patient

Dylan Probert as Catholic Choir Member

Amanda Beth as Nurse

Lariah Alexandria as Deshanah

Cecil Chatman as Orderly

Rory Gross as Tyler

Nigel Barto as Nurse

Edward James Warren as Portrait Son

Forrest Briggs as Paramedic

Eliseo Antonio Paredes as Doctor

Lize Johnston as The Demon Lamashtu

Patrick Roper as Teacher