Jason Segel as Jeff Thompkins

Ed Helms as Pat Thompkins

Susan Sarandon as Sharon Thompkins

Judy Greer as Linda Thompkins

Rae Dawn Chong as Carol

Steve Zissis as Steve

Evan Ross as Kevin

Matt Malloy as Barry

Benjamin Brant Bickham as TV Pitchman

Lee Nguyen as Clerk

Tim J. Smith as Guard

Ernest James as Guard

David Kency as Teammate

Raion Hill as Thug

Zac Cino as Gil

Lance E. Nichols as Elderly Man / Phone (voice)

Carol Sutton as Elderly Woman

Joe Chrest as Paul

Katie Aselton as Hostess

J.D. Evermore as Rob the Waiter

John Neisler as Kevin Kandy Employee

Ian Hoch as Bartender

Robert Larriviere as Manager

Jesse Moore as Taxi Driver

Scotty Whitehurst as Teen Driver

Wally Crowder as Fisherman

Carol Jean Wells as Younger Girl

Savanna Kinchen as Older Girl

Eddie Matthews as Father

Jennifer Lafleur as TV Announcer

Deneen Tyler as Woman Calling the Police

Randall Kamm as Field Reporter

Tammi Arender as Newscaster (uncredited)

Scheryl W Brown as Bistro Patron (uncredited)

Geraldine Glenn as Office Worker (uncredited)

Kassidy Ison as Little Girl with Afro Puffs (uncredited)

Rahsaana Ison as Parent in Arcade (uncredited)

Joy Kate Lawson as Child - Birthday and Video Arcade (uncredited)

Laurie Lee as Mother (uncredited)

Lisa Mackel Smith as Businesswoman (uncredited)

Lauren Rae Sullivan as Driver (uncredited)

Cindy Williamson as Office Worker (uncredited)