Seth Rogen as Andy Brewster

Barbra Streisand as Joyce Brewster

Yvonne Strahovski as Jessica

Colin Hanks as Rob

Brett Cullen as Ben

Adam Scott as Andrew Margolis Jr.

Ari Graynor as Joyce Margolis

Kathy Najimy as Gayle

Danny Pudi as Sanjay

Casey Wilson as Amanda

Dale Dickey as Tammy

Brandon Keener as Ryan Mcfee

Robert Curtis Brown as Bob Ferguson

Nora Dunn as Amy

Miriam Margolyes as Anita

Rose Abdoo as Diana

Analeis Anderson as Moonlight

Gabrielle Gumbs as Stripper

Rick Gonzalez as Mark

Worth Howe as Bob

Vicki Goldsmith as Young Joyce

Constance Esposito as HSN Executive

Creed Bratton as Suitor

Jeff Kober as Jimmy

Tom Virtue as Mature Singles Man

John Funk as K-Mart Executive

Julene Renee as K-Mart Receptionist (as Julene Renee-Preciado)

Matthew Levinson as Toddler Andy

Vivian Vanderwerd as Mature Singles Woman

Zabryna Guevara as K-Mart Executive

Michael Cassidy as Fake Andy (uncredited)