Meryl Streep as Kay

Tommy Lee Jones as Arnold Soames

Steve Carell as Dr. Bernie Feld

Jean Smart as Eileen, Kay's Friend

Marin Ireland as Molly, Their Daughter

Ben Rappaport as Brad, Their Son

Brett Rice as Vince, Arnold's Friend

Becky Ann Baker as Cora, The Waitress

Elisabeth Shue as Karen, The Bartender

Charles Techman as Charlie, The Docent

Danny Flaherty as Danny, The Bookstore Clerk

Damian Young as Mike, The Innkeeper

Mimi Rogers as Carol, The Neighbor

Ann Harada as Ann

Jack Haley as Jack, The Happy Husband

Patch Darragh as Mark, Their Son-in-Law

Susan Misner as Dana, Doctor Feld's Wife

Rony Clanton as Ronnie, The Taxi Driver

John Srednicki as John, The Waiter

Madeline Ruskin as Maddie, Brad's Girlfriend

Lee Cunningham as Lee, The Unhappy Wife

Paul Jude Letersky as Paul, The Unhappy Husband

Stephen Lee Davis as Steve, The Grocery Shopper

John Franchi as Driver (uncredited)

Anita Storr as Wedding Beach Goer (uncredited)