Garrett Hedlund as Dean Moriarty / Neal Cassady

Sam Riley as Sal Paradise / Jack Kerouac

Kristen Stewart as Marylou / LuAnne Henderson

Amy Adams as Jane / Joan Vollmer

Tom Sturridge as Carlo Marx / Allen Ginsberg

Kirsten Dunst as Camille / Carolyn Cassady

Viggo Mortensen as Old Bull Lee / William S. Burroughs

Danny Morgan as Ed Dunkle / Al Hinkle

Alice Braga as Terry / Bea Franco

Elisabeth Moss as Galatea Dunkel / Helen Hinkle

Terrence Howard as Walter

Sarah Allen as Vicki

Kim Bubbs as Laura

Eric Davis as Paul

Giselle Itié as Tonia

Steve Buscemi as Tall thin salesman

Giovanna Zacarías as Puta Loca Roja

Coati Mundi as Slim Gaillard

John Burnside as Ghostly Hobo (uncredited)

Omoze Idehenre as Black Woman

Kaniehtiio Horn as Rita Bettancourt

Joe Chrest as Virginia Cop

Rocky Marquette as Alfred

Jenessa Grant as Farmer’s Daughter (uncredited)

Kyle Gatehouse as Migrant Worker

Daniel Kash as Henry Glass