Charlize Theron as Andromache of Scythia / Andy

KiKi Layne as Nile Freeman

Matthias Schoenaerts as Sebastien Le Livre / Booker

Marwan Kenzari as Yusuf Al-Kaysani / Joe

Luca Marinelli as Nicolò di Genova / Nicky

Veronica Ngo as Quynh

Chiwetel Ejiofor as Copley

Uma Thurman as Discord

Henry Golding as Tuah

Kamil Nożyński as Louis

Slavko Sobin as Konrad

Christophe Tek as Watch Officer

Lorenzo Acquaviva as Food Stand Vendor

Peter Arpesella as Officer (voice)

Todd Cattell as Booker (voice)