Emily Blunt as Liza Drake

Chris Evans as Pete Brenner

Catherine O'Hara as Jackie

Andy García as Dr. Neel

Jay Duplass as Larkin

Brian d'Arcy James as Dr. Lydell

Amit Shah as Eric Paley

Chloe Coleman as Phoebe

Valerie LeBlanc as Laurene

Aubrey Dollar as Andy

Alex Klein as Sidney

Britt Rentschler as Camille

Michael Kosta as Guy Schatz

Nicholas Christopher McNeil as Randy

Bella Winkowski as Luna

Chapel Oaks as Daughter

Elle Lisic as Daughter

Willie Raysor as Matt

Selena Anduze as Kate

Josh Ventura as Dr. Jimmy

A.K. Benninghofen as Dr. Bowen

Chinet Scott as Nicole

Avis-Marie Barnes as Principal

Mike Stoudt as Banker

Lydia Castro as Banker

Nicole Sellars as Zanna Presenter

Adrian Enrique Hernandez as Clinic Receptionist

Rebecca Barnes as Clinic Office Staffer

Mandi Christine Kerr as Clinic RN

Joseph Mazza as Neurologist

Neil Kelly as Jason

Samantha Kacho as Catherine

Darryl L. Dillard as Podiatrist

Rowan Joseph as Podiatrist

Chris Marks as Jeff

Erica-Marie Sanchez as Applicant

Becca Breitfeller as Applicant

Andrea Laing as Ellen

Adrian Eppley as Heather

Greyson Chadwick as Maria

Hillary Harley as Tina

Devney Nixon as Pain Clinic Receptionist

Pat Dortch as Nervous Pain Clinic Doctor

Jeffrey Charles Morgan as Middle Aged Doctor

Jay Pearson as Georgia Doctor

Colby Burton as Ryan

Omer Mughal as Agent Simonetti

Cara Mantella as Admissions Officer

Forrest Conoly as Neel's Security Guy

Jamar Rivers as Neel's Security Guy

Dustin Lewis as Mr. Jorgenson

Mary Ann Hagan as Patient Outside Lydell's Clinic

Helen Ingebritsen as Patient Outside Lydell's Clinic

Alex Van as Patient Outside Lydell's Clinic

Quinn Bozza as Undercover D.E.A.

Donna DuPlantier as Jane Yagoda

Michael Lowry as Neel's Lawyer

Josefina Boneo as Forbes Reporter

Carolyn Jones Ellis as Adrienne's Mom

Elijah Forbes as Emma Kowalski's Son

Ryan King as Sam Walter's Husband

David Kronawitter as Dr. Hartigan

Jackie Goldston as Judge

Leydi Morales as Loan Agent

Abigail Susan Williams as Lindsay - Chemo Headwrap Patient

Jackson Abram as Matt's Son

Tristan Shufford as Matt's Son

Alex Mitchell as Liza's Courtroom Attorney

Maria Sager as Neel's Housekeeper

Olga Lee as Rental Agent

Brandon Stanley as Drama Teacher

Hannah Pniewski as Surgical Nurse

Erin Ownbey as Young Jackie

Kaysi J. Bradley as Girl Next to Phoebe

Snowden Grey as Cinda

Alan Wells as Gambling Anonymous Doctor

Cliff Lanning as Crooning Doctor

Valerie Boafo as Extended Stay Resident

Sharon Conley as Judge Susan Holman

Lisa Travis as Group Leader

Desmond Phillips as Bartender

Matthew Butcher as Bartender

Nick Arapoglou as Bartender

Kheri Symone as Phoebe's Friend at School

Kirsten Lee Anderson as Clinic Mother

Bliss Browne as Balinese Dancer

Blythe Browne as Balinese Dancer

Joy Browne as Balinese Dancer

Emily Huhtanen as Balinese Dancer

Savannah Johnson as Balinese Dancer

Jasmine Lee-Jones as Balinese Dancer

Ka'iulani Mcintosh-Ross as Balinese Dancer

Kelsey Muckle as Balinese Dancer

Isabel Smith as Balinese Dancer

Noor Tomeh as Balinese Dancer

Alexis Baca as Pharmaceutical Model (uncredited)

Tris Marie as Lydell Nurse (uncredited)

Shelley Jane as Nervous Doctor's Crush (uncredited)