Boris Karloff as James Rankin

Jean Kent as Cora Seth

Elizabeth Allan as Barbara Rankin

Anthony Dawson as Supt. Burk

Vera Day as Pearl

Tim Turner as Dr. Kenneth McColl

Diane Aubrey as Lily Rankin

Max Brimmell as Newgate Prison Turnkey

Leslie Perrins as Newgate Prison Governor

Jessica Cairns as Asylum Maid

Dorothy Gordon as Hannah

Desmond Roberts as Dr. Johnson

Roy Russell as Medical Superintendent

Derek Birch as Guyse Hospital Superintendent

Peggy Ann Clifford as Kate

John Fabian as Young Blood

Joan Elvin as Can-Can Girl

Audrey Sykes as Laughing Lady at Hanging (uncredited)

Marie Devereux as Show Girl (uncredited)