Willem Dafoe as Cisco

Shanyn Leigh as Skye

Toni Redman as Man on phone (voice)

Pat Kiernan as News Anchor

Francis Kuipers as Teddy

Selena Mars as Skype Dancer

Justin Restivo as Suicide

Bojana Vasik as Woman with coat

Trung Nguyen as Delivery Boy

Triana Jackson as Cisco's Daughter

Dierdra McDowell as Cisco's Ex

Natasha Lyonne as Tina

Anita Pallenberg as Sky's Mother

Paul Hipp as Noah

José Solano as Drug Dealer

Judith Salazar as Friend of Dealer

Paz de la Huerta as Woman on Street

Frank Aquilino as Man Outside Bar

Maria Grazia Schirripa as Wailing Woman

Muriel Sprissler Dafoe as Cisco's Mother

Nicholas Deceolia as Man in Window

Tenzin Gyatso as Self (archive footage) (uncredited)

Al Gore as Self (archive footage) (uncredited)

Anthony Perullo as Contrition (uncredited)

Charlie Rose as Self (archive footage) (uncredited)

Tyler Stone as Man in Heels (uncredited)

Thomas Michael Sullivan as Priest (uncredited)

Nicola Tranquillino as Newscaster (uncredited)