Marlene Dietrich as Shanghai Lily

Clive Brook as Captain Donald 'Doc' Harvey

Anna May Wong as Hui Fei

Warner Oland as Mr. Henry Chang

Eugene Pallette as Sam Salt

Lawrence Grant as Reverend Carmichael

Louise Closser Hale as Mrs. Haggerty

Gustav von Seyffertitz as Eric Baum

Émile Chautard as Major Lenard

George Blagoi as Minor Role (uncredited)

Leonard Carey as Carey (uncredited)

George Chung as Chinese Soldier (uncredited)

Wong Chung as Chinese Officer Checking Passports (uncredited)

Jack Deery as British Officer at Shanghai (uncredited)

Herbert Evans as British Railway Officer (uncredited)

Willie Fung as Train Engineer (uncredited)

Tom Gubbins as Chinese Officer (uncredited)

Forrester Harvey as Peiping Ticket Agent (uncredited)

Claude King as Mr. Albright (uncredited)

James B. Leong as A Rebel (uncredited)

Miki Morita as Chinese Officer (uncredited)

Minoru Nishida as Li Fung (uncredited)

Victor Wong as Chinese Officer (uncredited)

Ura Mita as Chinese Woman (uncredited)