Amy Poehler as Angie Ostrowiski

Tina Fey as Kate Holbrook

Greg Kinnear as Rob Ackerman

Dax Shepard as Carl Loomis

Romany Malco as Oscar Priyan

Sigourney Weaver as Chaffee Bicknell

Steve Martin as Barry Waterman

Maura Tierney as Caroline

Stephen Mailer as Dan

Holland Taylor as Rose

James Rebhorn as Judge

Denis O'Hare as Dr. Manheim

Kevin Collins as Architect / Rick

Will Forte as Scott

Fred Armisen as Stroller Salesman

John Hodgman as Fertility Specialist

Siobhan Fallon Hogan as Birthing Teacher

Tom McCarthy as Kate's Date

Jason Mantzoukas as Gay Couple

Dave Finkel as Gay Couple

Brian Stack as Dave

Felicity Stiverson as Wiccan

Anne L. Nathan as Bookstore Clerk

Jay Phillips as Boo-Boo Buster

Kathy Searle as Cool Mom

Almeria Campbell as Maternity Nurse

Alice Kremelberg as Rob's Daughter

Catherine Rose as Caroline's 4 Year Old

Ian Colletti as Caroline's 7 Year Old

Eric Zuckerman as Community Member

Frank Rodriguez as Community Member

Diane Cheng as Community Member

Andra Eggleston as Waitress

Andrew Hillmedo Jr. as Dante

Jon Glaser as Vegan Waiter

Erica Fae as Yoga Mom

Curt Carlson as Bailiff

Jeffrey Mowery as Irish Tourist (uncredited)