Steve Carell as Dodge Petersen

Keira Knightley as Penelope "Penny" Lockhart

Connie Britton as Diane

Rob Corddry as Warren

Adam Brody as Owen

Derek Luke as Alan Speck

Martin Sheen as Frank Petersen

Melanie Lynskey as Karen Amalfi

Nancy Carell as Linda Petersen

William Petersen as Trucker

Gillian Jacobs as Waitress / Katie

T.J. Miller as Chipper Host / Darcy

Patton Oswalt as Roache

Bob Stephenson as Officer Wally Johnson

Brad Morris as Radio Announcer (voice)

Mark Moses as Anchorman

Roger Aaron Brown as Alfred

Rob Huebel as Jeremy

Trisha Gorman as Crying Woman

Tonita Castro as Elsa

Leslie Murphy as Amy

Kasey Campbell as Danny

Vince Grant as Man #1 / Chip

Amy Schumer as Woman #1 / Lacey

Marshall Manesh as Indian Man

Aleister as Sorry

Rene Gube as Cell-Mate

Jim O'Heir as Cop #2

Daniel Maurio as Toilet Guy

Matthew Alan Brady as Kissing Couple In Park (uncredited)

Tony Brown as Gay Party Guest (uncredited)

Lauren Crawford as Bikini Girl (uncredited)

Laura Mann as Sarah (uncredited)

Prestin Persson as Bikini Girl (uncredited)

Lauren K. Solomon as Kissing Friendsy's Customer (uncredited)

Chris Spinelli as Cyclist (uncredited)

Hannah Victoria Stock as Party Girl (uncredited)