Roberto Benigni as Roberto (segment "Strange to Meet You")

Steven Wright as Steven (segment "Strange to Meet You")

Joie Lee as Good Twin (segment "Twins")

Cinqué Lee as Evil Twin (segment "Twins") / Kitchen Guy (segment "Jack...")

Steve Buscemi as Danny (segment "Twins")

Iggy Pop as Iggy (segment "Somewhere in California")

Tom Waits as Tom (segment "Somewhere in California")

Joseph Rigano as Joe (segment "Those Things'll Kill Ya")

Vinny Vella as Vinny (segment "Those Things'll Kill Ya")

Vinny Vella, Jr. as Vinny Jr. (segment "Those Things'll Kill Ya")

Renée French as Renée (segment "Renée")

E.J. Rodriguez as Waiter (segment "Renée")

Alex Descas as Alex (segment "No Problem")

Isaach de Bankolé as Isaach (segment "No Problem")

Cate Blanchett as Cate / Shelly (segment "Cousins")

Michael Hogan as Waiter (segment "Cousins")

Jack White as Jack (segment "Jack Shows Meg His Tesla Coil")

Meg White as Meg (segment "Jack Shows Meg His Tesla Coil")

Alfred Molina as Alfred (segment "Cousins?")

Steve Coogan as Steve (segment "Cousins?")

Katy Hansz as Katy (segment "Cousins?")

The GZA as GZA (segment "Delirium")

RZA as RZA (segment "Delirium")

Bill Murray as Bill Murray (segment "Delirium")

William Rice as Bill (segment "Champagne")

Taylor Mead as Taylor (segment "Champagne")