Mckenna Grace as Skye (voice)

Taraji P. Henson as Victoria Vance (voice)

Marsai Martin as Liberty (voice)

Christian Convery as Chase (voice)

Ron Pardo as Mayor Humdinger / Cap'n Turbot (voice)

Lil Rel Howery as Sam Stinger (voice)

Kim Kardashian as Delores (voice)

Chris Rock as Kitty (voice)

Serena Williams as Yoga Yvette (voice)

Alan Kim as Nano (voice)

Brice González as Tot (voice)

North West as Mini (voice)

Saint West as Meteor Max (voice)

James Marsden as Hank (voice)

Kristen Bell as Janet (voice)

Finn Lee-Epp as Ryder (voice)

Christian Corrao as Marshall (voice)

Luxton Handspiker as Rubble (voice)

Nylan Parthipan as Zuma (voice)

Callum Shoniker as Rocky (voice)

Dan Duran as Radio Announcer (voice)

Kim Roberts as Mayor Goodway (voice)

Sugith Varughese as Jail Guard (voice)

Joshua Graham as Computer voice (voice)

Monique Alvarez as Carmen (voice)

Neil Crone as Tony (voice)

Stephane Belong as Computer (voice)

Valentina Tronel as (voice) (uncredited)

Sofia Essaïdi as (voice) (uncredited)

Guillaume Aldebert as (voice) (uncredited)

Marianne James as (voice) (uncredited)