Chevy Chase as Emmett Fitz-Hume

Dan Aykroyd as Austin Millbarge

Steve Forrest as General Sline

Donna Dixon as Karen Boyer

Bruce Davison as Ruby

Terry Gilliam as Dr. Imhaus

Frank Oz as Test Monitor

Vanessa Angel as Russian Rocket Crewperson

Bernie Casey as Colonel Rhumbus

Charles McKeown as Jerry Hadley

William Prince as Keyes

Bob Hope as Self

Joel Coen as Drive-In Security

Sam Raimi as Drive-In Security

Martin Brest as Drive-In Security

Tom Hatten as General Miegs

James Daughton as Bob Hodges

Jim Staahl as Bud Schnelker

Bjarne Thomsen as Russian Rocket Crewperson

Sergey Rusakov as Russian Rocket Crewperson

Costa-Gavras as Tadzhik Highway Patrolman

Seva Novgorodtsev as Tadzhik Highway Patrolman

Stephen Hoye as Captain Hefling

Ray Harryhausen as Dr. Marston

Mark Stewart as Ace Tomato Courier

Sean Daniel as Ace Tomato Driver

Jeff Harding as Fitz-Hume's Associate

Heidi Sorenson as Alice, Fitz-Hume's Supervisor

Margo Random as Reporter

Douglas Lambert as Reporter

Christopher Malcolm as Jumpmaster

Terrance Conder as Soldier #1

Matt Frewer as Soldier #2

Tony Cyrus as The Khan

Gusti Bogok as Dr. La Fong

Derek Meddings as Dr. Stinson

Robert Paynter as Dr. Gill

Gurdial Sira as The Khan's Brother

Michael Apted as Ace Tomato Agent

B.B. King as Ace Tomato Agent

Larry Cohen as Ace Tomato Agent

Ricco Ross as WAMP Guard

Richard D. Sharp as WAMP Technician

Stuart Milligan as WAMP Technician

Sally Anlauf as WAMP Technician

John Daveikis as Russian Border Guard

Laurence Bilzerian as Russian Border Guard

Richard Kruk as Russian Border Guard

Heather Henson as Teenage Girl

Erin Folsey as Teenage Girl

Bob Swaim as Special Forces Commander

Nancy Gair as Student (uncredited)

Guy Standeven as Reporter (uncredited)