Julia Roberts as Mary Reilly

John Malkovich as Dr. Henry Jekyll / Edward Hyde

George Cole as Mr. Poole

Michael Gambon as Mary’s Father

Glenn Close as Mrs. Farraday

Kathy Staff as Mrs. Kent

Michael Sheen as Bradshaw

Bronagh Gallagher as Annie

Linda Bassett as Mary's Mother

Ciarán Hinds as Sir Danvers Carew

Henry Goodman as Haffinger

Wendy Nottingham as Screaming Girl's Mother

Moya Brady as Young Woman

Emma Griffiths Malin as Young Whore

Sasha Hanau as Young Mary

Isabella Marshall as Screaming Girl

Richard Leaf as Screaming Girl's Father

Stephen Boxer as Inspector

Tim Barlow as Vicar

Harry Fielder as Man with Beard (uncredited)