Matthew Broderick as Dr. Niko Tatopoulos

Jean Reno as Philippe Roaché

Maria Pitillo as Audrey Timmonds

Hank Azaria as Victor 'Animal' Palotti

Kevin Dunn as Colonel Hicks

Michael Lerner as Mayor Ebert

Harry Shearer as Charles Caiman

Arabella Field as Lucy Palotti

Vicki Lewis as Dr. Elsie Chapman

Doug Savant as Sergeant O'Neal

Malcolm Danare as Dr. Mendel Craven

Lorry Goldman as Gene, Mayor's Aide

Christian Aubert as Jean-Luc

Philippe Bergeron as Jean-Claude

Frank Bruynbroek as Jean-Pierre

François Giroday as Jean-Philippe

Nicholas J. Giangiulio as Ed

Robert Lesser as Murray

Ralph Manza as Old Fisherman

Greg Callahan as the Governor

Chris Ellis as General Anderson

Nancy Cartwright as Caiman's Secretary

Richard Gant as Admiral Phelps

Jack Moore as Leonard

Steve Giannelli as Jules

Brian Farabaugh as Arthur

Stephen Xavier Lee as Lt. Anderson

Bodhi Elfman as Freddie

Rich Grosso as Jimmy

Lloyd Kino as Japanese Tanker Cook

Toshi Toda as Japanese Tanker Captain

Clyde Kusatsu as Japanese Tanker Skipper

Masaya Katō as Japanese Tanker Crew Member

Glenn Morshower as Kyle Terrington

Lola Pashalinski as Pharmacist

Rob Fukuzaki as WIDF Co-Anchor

Dale Harimoto as WKXI Anchor

Gary W. Cruz as WFKK Anchor

Derek Webster as Utah Captain

Stuart Fratkin as Utah Ensign

Frank Cilberg as Utah Sailor

Jason Edward Jones as Utah Sailor

Roger McIntyre as Utah Sailor

David Pressman as Anchorage Captain

Robert Faltisco as Anchorage Ensign

Christopher Darius Maleki as Anchorage Ensign

Scott Lusby as Anchorage Ensign

Ali Afshar as Anchorage Sailor

Terence Paul Winter as Apache Pilot

Kirk Geiger as Apache Pilot

Pat Mastroianni as Apache Pilot

Eric Saiet as Apache Pilot

Burt Bulos as Apache Pilot

Robert Floyd as Apache Pilot

Seth Peterson as Apache Pilot

Jamison Yang as F-18 Pilot

Nathan Anderson as F-18 Pilot

Mark Munafo as F-18 Pilot

Dwight Schmidt as F-18 Pilot

Dwayne Swingler as Raven Pilot #2

Lawton Paseka as Officier

Greg Collins as Soldier on the Bridge

James Black as Soldier

Thomas Giuseppe Giantonelli as Soldier

Paul Ware as Soldier

Montae Russell as Soldier on Plane

Christopher Carruthers as Radio Technician

Daniel Pearce as Radio Technician

Mark Fite as Radio Operator

Craig 'Radio Man' Castaldo as Radio Man

Eric Paskel as Rodgers

Lee Weaver as Homeless Guy

Leonard Termo as Homeless Guy

Joshua Taylor as Spotter

Al Sapienza as Taxi Cab Driver

Stoney Westmoreland as Tunnel Guard

Gary Warner as Gun Technician

Ed Wheeler as New York Cop

Bill Hoag as New Jersey Cop

Joseph Badalucco Jr. as Forklift Driver

Jonathan Dienst as Field Reporter

Benjamin Baird as Reporters

Madeline McFadden as Reporter

Julian M. Phillips as Reporter

Raymond Ramos as Reporter

Gary A. Hecker as Creature Vocals (voice)

Frank Welker as Creature Vocals (voice)

Al Leong as Japanese Fishing Boat Crewman

Ed Godziszewski as Bridge Onlooker (uncredited)

Steven Ho as Japanese Fishing Boat Crewman (uncredited)

George Cheung as Japanese Fishing Boat Crewman (uncredited)

John Koyama as Japanese Fishing Boat Crewman (uncredited)

Al Goto as Japanese Fishing Boat Crewman (uncredited)

Norman Fessler as WIDF News Worker in Elevator (uncredited)