James Stewart as Paul Biegler

Lee Remick as Laura Manion

Ben Gazzara as Lt. Frederick Manion

Arthur O'Connell as Parnell Emmett McCarthy

Eve Arden as Maida Rutledge

Kathryn Grant as Mary Pilant

George C. Scott as Claude Dancer

Orson Bean as Dr. Matthew Smith

Russ Brown as George Lemon

Murray Hamilton as Alphonse Paquette

Brooks West as Dist. Atty. Mitch Lodwick

Ken Lynch as Det. Sgt. James Durgo

John Qualen as Deputy Sheriff Sulo

Howard McNear as Dr. Dompierre

Alexander Campbell as Dr. W. Gregory Harcourt

Ned Wever as Dr. Raschid

Jimmy Conlin as Clarence Madigan

Royal Beal as Sheriff Battisfore

Joseph Kearns as Lloyd Burke

Don Ross as Duane 'Duke' Miller

Lloyd Le Vasseur as Court Clerk

James Waters as Army Sergeant 1st Class

Joseph N. Welch as Judge Weaver

Duke Ellington as Pie Eye (uncredited)

Irv Kupcinet as Distinguished Gentleman (uncredited)

Chuck Ramsay as Orderly (uncredited)

Agnes Rodgers Brown as Juror (uncredited)