James Stewart as Paul "Pauly" Biegler

Lee Remick as Laura Manion

Ben Gazzara as Lieutenant Frederick "Manny" Manion

Arthur O'Connell as Parnell Emmett "Parn" McCarthy

Eve Arden as Maida Rutledge

Kathryn Grant as Mary Pilant

George C. Scott as AAG Claude Dancer

Orson Bean as Dr. Matthew Smith

Russ Brown as Deputy Sheriff George Lemon

Murray Hamilton as Alphonse "Al" Paquette

Brooks West as DA Mitchell "Mitch" Lodwick

Ken Lynch as Det. Sgt. James "Jim" Durgo

John Qualen as Deputy Sheriff Sulo Kangas

Howard McNear as Dr. Adelord Dompierre

Alexander Campbell as Dr. W. Gregory Harcourt

Ned Wever as Dr. Homer Raschid

Jimmy Conlin as Clarence "One-Shot" "Smoky" Madigan

Royal Beal as Sheriff Max Battisfore

Joseph Kearns as Lloyd Burke

Don Ross as Duane "Duke" Miller

Lloyd Le Vasseur as Court clerk

James Waters as Army Sergeant 1st Class

Joseph N. Welch as Judge Harlan Weaver

Duke Ellington as Pie Eye (uncredited)

Irv Kupcinet as Distinguished Gentleman (uncredited)

Chuck Ramsay as Orderly (uncredited)

Agnes Rodgers Brown as Juror (uncredited)