Marlon Brando as Dr. Moreau

Val Kilmer as Montgomery

David Thewlis as Douglas

Fairuza Balk as Aissa

Daniel Rigney as Hyena-Swine

Temuera Morrison as Azazello

Nelson de la Rosa as Majai

Peter Elliott as Assassimon

Mark Dacascos as Lo-Mai

Ron Perlman as Sayer of the Law

Marco Hofschneider as M'Ling

Miguel López as Waggdi

Neil Young as Boar Man

David Hudson as Bison Man

Clare Grant as Fox Lady

Kitty Silver as Sow Lady #1

Fiona Mahl as Sow Lady #2

William Hootkins as Kiril

Agoes Widjaya Soedjarwo as Captain

Ron Vreeken as Soldier #1

Lou Horváth as Soldier #2

Morgan Smallbone as Dog Man (uncredited)

Richard Stanley as Melting Bulldog (uncredited)

Frank Welker as Assassimon (voice) (uncredited)