Andra Day as Ebony Jackson

Glenn Close as Alberta Jackson

Anthony B. Jenkins as Andre Jackson

Caleb McLaughlin as Nate Jackson

Demi Singleton as Shante Jackson

Aunjanue Ellis-Taylor as Rev Bernice James

Mo'Nique as Cynthia Henry

Omar Epps as Melvin

Miss Lawrence as Asia

Javion Allen as Neighborhood Kid #1

Todd Anthony as Ahman

Bryant Bentley as Usher

Colleen Camp as Doctor Hoffsteder

Cynthia Dallas as Nurse

Amy Lyn Elliott as Chemo Patient

I.C. Greene as Neighborhood Kid #2

Ahman Green as Neighborhood Kid #3

Ellis Hobbs IV as Trey

Jeff Hochendoner as Brave Samaritan

Juanita Jennings as Mrs. Tucker

Phong Le as Exterminator

Kimberly Russell as Mrs. Ross

Tasha Smith as Pastor Powell

Tajinae Turner as Young Ebony

James William O'Halloran as Satan

Dominique Toney as Janelle

Malieek Straughter as Leek

Lorenzo Zottoli as High School Teen