Aaron Eckhart as Dr. Josh Keyes

Hilary Swank as Maj. Rebecca Childs

Delroy Lindo as Dr. Ed 'Braz' Brazzleton

Stanley Tucci as Dr. Conrad Zimsky

Tchéky Karyo as Serge

DJ Qualls as Theodore Donald 'Rat' Finch

Richard Jenkins as Gen. Thomas Purcell

Bruce Greenwood as Cmdr. Robert Iverson

Christopher Shyer as Dave Perry

Ray Galletti as Paul

Eileen Pedde as Lynne

Rekha Sharma as Danni

Tom Scholte as Acker

Glenn Morshower as FBI Agent

Anthony Harrison as FBI Agent

Alfre Woodard as Stickley

Fred Keating as Court-Martial Presiding Officer

Bart Anderson as Dad

Nicole Leroux as Mom

Justin Callan as Little Boy

Chris Humphreys as GBTV Reporter - Trafalgar Square

Dion Johnstone as Flight Engineer Timmins

Fred Ewanuick as Endeavor Flight Engineer

Hrothgar Mathews as Chief Engineer Mission Control

Ming-Tzong Hong as Scientist

Jennifer Spence as Zimsky's Assistant

Michael St. John Smith as Pentagon General

John Shaw as FBI Agent - Rat's Apartment

Nickolas Baric as Security Policeman - Tribunal

Rosa Di Brigida as Rome Café Patron

Roberto Roberto as Rome Café Patron

Ermanno De Biagi as Rome Café Patron

Marcello Laurentis as Rome Café Patron

Matt Winston as Luke Barry

Claire Riley as News Anchor

Marke Driesschen as News Anchor

Laurie Murdoch as Project Destiny Engineer

Costa Spanos as Project Destiny Engineer

Monique Martel as Paris Café Lady

Lenie Scoffié as Paris Café Lady

Nathaniel DeVeaux as U.S.S. Constellation Captain

Robert Manitopyes as U.S.S. Constellation Screen Ops

Alejandro Abellan as U.S.S. Soldier (uncredited)

Benjamin Barton as Scientist / Extra (uncredited)

Angelica Hayden as Coffeehouse Patron (uncredited)

Robert Paul Lewis as Beach-goer (uncredited)

Alec Medlock as (voice) (uncredited)

Alonso Oyarzun as Security Policeman (uncredited)

Priscilla Poland as Scientist (uncredited)

Shawn Green as Himself

Greg Bennett as Technician - Virgil Base

Jeffrey Gold as Engineer (uncredited)

Rick Kain as Chief Petty Officer (uncredited)

Pamela Martin as News Anchor (uncredited)