Rihanna as Smurfette (voice)

James Corden as No Name (voice)

Nick Offerman as Ken (voice)

JP Karliak as Gargamel / Razamel (voice)

Dan Levy as Joel (voice)

Amy Sedaris as Jaunty (voice)

Natasha Lyonne as Mama Poot (voice)

Sandra Oh as Moxie Smurf (voice)

Jimmy Kimmel as Tardigrade (voice)

Octavia Spencer as Asmodius (voice)

Nick Kroll as Chernobog (voice)

Hannah Waddingham as Jezebeth (voice)

Alex Winter as Hefty Smurf (voice)

Maya Erskine as Vanity Smurf (voice)

Billie Lourd as Worry Smurf (voice)

Xolo Mariduena as Brainy Smurf (voice)

Kurt Russell as Ron (voice)

John Goodman as Papa Smurf (voice)

Chris Miller as Grouchy Smurf / Camouflage Smurf (voice)

Rachel Butera as Azrael / List Maker Smurf (voice)

Conrad Vernon as Butler (voice)

Tyler Peterson as Bellhop (voice)

Marshmello as Turtle (voice)

Chris Prynoski as Quiet Smurf / Way Back There Smurf / Shark Taming Smurf (voice)

Spencer X as Sound Effects Smurf (voice)

Hugo Miller as Clumsy Smurf (voice)

Ryan Naylor as Calendar Smurf (voice)

Jonny Manganello as Baker Smurf (voice)

DJ Snake as DJ Snake (voice)

Léa Elui as Featured Paris Disco Dancer (voice)

Yuuki Luna as Smurfette Anime (voice)

Daisuke Tsuji as No Name Anime (voice)

Keisuke Hoashi as Razamel Anime (voice)